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Welcome to the NBL! We study biosystems at the nanoscale (macromolecular and sub-molecular levels). In particular, we are interested in how subtle changes in the chemical structure of biomolecules lead to diverse functionality. Understanding these rules allow us to make materials with emergent physical and chemical properties, and towards this we are developing techniques that probe at molecular and sub-molecular levels the properties of natural and synthetic biopolymers. Techniques used in the lab include micro- and nano-fabrication, organic and inorganic thin film deposition, interfacial chemistry and bioconjugate chemistry, scanning probe microscopy, vibrational spectroscopy, electronic/optical measurements, and molecular biology.

-05/26/14 Congrats to Bobby and Carolyn on acceptance of your paper on RNA conformational analysis!

-Download “Nanopores: A journey towards DNA sequencing” here.

-12/16/13 Congrats to Joe and Bobby on acceptance of your paper on protein detection!

-10/01/13 Congrats to Joe and Bobby on your new paper, just accepted!

-09/30/13 Congrats to Andrey and Spencer on your new paper, just accepted!

-09/18/13 Congrats to Bobby on his passing the quals!

-08/21/2013: Visit to Amherst resulted in us gaining a lot of potential energy! We learned that losing potential energy is as difficult as gaining it, when the energy landscape is rough.

-05/02/2013: We had a good time in the annual NHGRI meeting in San Diego. Some of us learned that playing matkot is not easy…

 

-12/18/2012: New paper on “Electrically-Controlled Nanoparticle Synthesis inside Nanopores” available here.

-09/14/2012: Our group was awarded an NIH grant for improving waveguide-based DNA sequencing (in collaboration with PacBio).

-08.2012: Tzahi and Mirela’s work on AFM of nanocomposite silk fibers is featured in a new paper in Nano Letters.

-08.2012: Dan and Spencer are shown in the Today Show (08/20/2012). In a recent survey by Princeton Review, Northeastern’s famous co-op program earned it the title of top school for Career Services in the US (see article and video here)!

 

-07.2012: Physics of Life Review entitled: “Nanopores: A journey towards DNA sequencing” is out: [pdf]

- 07/2012: We had fun at the 1st annual group picnic in Brookline, MA:

- 06/14/2012: Review entitled Nanopores: A journey towards DNA sequencing is now available online in Physics of Life Reviews (also see comments on article in the same issue).

- 4/19/2012: Our group was awarded two NEU Tier 1 research awards for collaborative research on 1) single-crystal freestanding membrane fabrication and 2) platform for cellular imaging.

- 2/24/2012: Congrats Jacob Rosenstein from the Shepard group at Columbia U. for great work on the MHz current amplifier, now in Nature Methods (see here).

- 2/21/2012: Congrats Luke Somers on your ICAM postdoctoral fellowship (a collaboration between Rutgers and our group)!

- 2/1/2012: Andrey Ivankin, welcome to our group! Andrey is coming from the group of David Gidalevitz at the Illinois Institute of Technology. Andrey is a post-doctoral researcher with expertise in structural characterization of biological membranes and membrane-active peptides.

- 1/11/2012: Mirela Mustata, welcome to our group! We are excited to have you. Mirela is a post-doctoral researcher with vast expertise in atomic force microscopy of biological systems.

- 12/15/2011: Prof. Yitzhak Tor and I have published a new book that surveys modern experimental and computational methods for analyzing nucleic acid/drug interactions (available on Amazon.com).

- New publication on nanopore-based detection of RNA/antibiotic complexes (work highlighted in the next issue of C&E News and also highlighted in ACS’s In Nano). In collaboration with Prof. Yitzhak Tor at the University of California, San Diego, complexes of prokaryotic A-site RNA with amino glycosides were detected using an ultrathin silicon nitride-based nanopore sensor.

- Recent work has been highlighted in s special issue of the 5th anniversary of Nature Nanotechnology.