Publications

Peer-reviewed publications (in chronological order)

  • Balaconis, M.K., Cash, K., Billingsley, K., and Clark, H.A., Formulation of Fluorescent Nano-optodes for Glucose Detection, Journal of Diabetes Technology, 2010, in presss.
  • Dubach, J.M., Zhang, N., Lim, E., Francis, K.P., and Clark, H.A., In vivo sodium concentration continuously monitored with fluorescent sensors, Integrative Biology, 2010, ASAP published November 19.
  • Billingsley, K., Balaconis, M.K., Dubach, J.M., Zhang, N., Lim, E., Francis, K.P., and Clark, H.A., Fluorescent Nano-optodes for Glucose Detection, Analytical Chemistry, 2010, 82 (9), pp 3707–3713.
  • J. Varsanik, W. Teynor, J. LeBlanc, H. Clark, J. Krogmeier, T. Yang, K. Crozier, J. Bernstein, “Sub-wavelength plasmonic readout for direct linear analysis of optically tagged DNA” , SPIE BIOS 2010, Paper # 7577-26, San Francisco, CA, 23-28th January 2010.
  • Dubach, J.M., Das, S., Rosenzweig, A., and Clark, H.A., Visualizing Sodium Dynamics in Isolated Cardiomyocytes Using Fluorescent Nanosensors, PNAS, 2009; 106 (38); 16145-16150.
  • Harjes, D.I., Dubach, J.M., Das, S., Rosenzweig, A., and Clark, H.A., Ion-Selective Optodes Measure Extracellular Potassium Flux in Excitable Cells, Macromolecular Rapid Communications (invited), 2009; 30 (2), 217-221.
  • Baxamusa, S.H., Montero, L., Dubach, J.M., Clark, H.A., Borros, S., and Gleason, K.K., Protection of sensors for biological applications by photinitiated chemical vapor deposition (piCVD) of hydrogel thin films, Biomacromolecules, 2008; 9 (10); 2857–2862.
  • Dubach, J.M., Harjes, D.I., and Clark, H.A., Ion-Selective Nano-Optodes Incorporating Quantum Dots, Journal of the American Chemical Society, 2007, Journal of the American Chemical Society, 2007; 129 (27); 8418-8419.
  • Dubach, J.M., Harjes, D.I., and Clark, H.A., Fluorescent Nanosensors for Intracellular Analysis with Improved Lifetime and Size, Nano Letters, 2007; 7(6); 1827-1831.
  • Jin, L., Millard, A.C., Wuskell, J.P., Dong, X., Wu, D., Clark, H.A., and Loew, L.M., Characterization and Application of a New Optical Probe for Membrane Lipid Domains, Biophysical Journal, 2006; 90 (7); 2563-2575.
  • Shnayderman, M.; Mansfield, B.; Yip, P.; Clark, H. A.; Krebs, M. D.; Cohen, S. J.; Zeskind, J. E.; Ryan, E. T.; Dorkin, H. L.; Callahan, M. V.; Stair, T. O.; Gelfand, J. A.; Gill, C. J.; Hitt, B.; Davis, C. E.; Species-Specific Bacteria Identification Using Differential Mobility Spectrometry and Bioinformatics Pattern Recognition, Analytical Chemistry, 2005; 77(18); 5930-5937.
  • Jin, L., Millard, A.C., Wuskell, J.P., Clark, H.A., and Loew, L.M., Cholesterol-Enriched Lipid Domains Can Be Visualized by di-4-ANEPPDHQ with Linear and Nonlinear Optics, Biophysical Journal,  2005; 89; L04-6L.
  • Brasuel, M., Kopelman, R., Aylott, J.W., Clark, H.A., Xu, H., Hoyer, M., Miller, T.J., Tjalkens, R., Philbert, M.A., Production, Characteristics and Applications of Fluorescent PEBBLE Nanosensors: Potassium, Oxygen, Calcium and pH Imaging Inside Live Cells, Sensors and Materials, 2002; 14(6), 309-338.
  • Campagnola, P.J., Clark, H.A., Mohler, W.A., Lewis, A. and Loew, L.M., Second Harmonic Imaging Microscopy of Living Cells, Journal of Biomedical Optics, 2001; 6(3); 277-286.
  • Clark, H.A., Campagnola, P.J., Wuskell, J.P., Lewis, A. and Loew, L.M., Second Harmonic Generation Properties of Fluorescent Polymer-Encapsulated Gold Nanoparticles, Journal of the American Chemical Society, 2000; 122(41); 10234-10235.
  • Clark, H.A., Merritt, G. and Kopelman, R., Novel Biosensors Using a Gold Colloid Monolayer Substrate, SPIE Proceedings, 2000; 3922; 138-146.
  • Clark, H.A., Hoyer, M., Philbert, M.A. and Kopelman, R., Optical Nanosensors for Chemical Analysis inside Single Living Cells.  Part 1: Synthesis and Characterization, Analytical Chemistry, 1999; 71(21); 4831-4836.
  • Clark, H.A., Kopelman, R., Tjalkens, R. and Philbert, M.A., Optical Nanosensors for Chemical Analysis inside Single Living Cells.  Part 2: Intracellular Sensors for Calcium and pH, Analytical Chemistry, 1999; 71(21); 4837-4843.
  • Clark, H.A., Hoyer, M., Philbert, M.A., and Kopelman, R., Intracellular Optochemical Nanosensors, Mikrochimica Acta, 1999; 131; 121-128.
  • Barker, S.L.R., Clark, H.A., Swallen, S.F., Kopelman, R., Tsang, A.W., Swanson, J.A., Development and Applications of Ratiometric and Fluorescence Lifetime Based Biosensors for Detection of Extra- and Intracellular Macrophage Nitric Oxide, Analytical Chemistry, 1999; 71(9); 1767-1772.
  • Kopelman, R., Miller M.T., Brasuel, M., Clark, H.A., Hoyer, M. and Philbert, M.A., Optochemical Nanosensors for Intracellular Chemical Measurement, SPIE Proc, 1999, 3540, 198-205.
  • Chen-Esterlit, Z., Peteu, S.F., Clark, H.A., McDonald, W., and Kopelman, R., A Comparative Study of Optical Fluorescent Nanosensors (PEBBLEs) and Fiber Optic Microsensors for Oxygen Sensing, SPIE Proc, (1999) 3602, 156-163.
  • Clark, H.A., Kopelman, R., et. al., Subcellular Optochemical Nanobiosensors: Probes Encapsulated by Biologically Localized Embedding (PEBBLEs), Sensors and Actuators B, 1998; 51; 12-16.

Publications (Book Chapters)

  • “PEBBLE Nanosensors for Real Time Intracellular Chemical Imaging”, Brasuel, M., Kopelman, R., Philbert, M.A., Aylott, J.W., Clark, H.A., Kasman, I., King, M., Monson, E., Sumner, J., Xu, H., Hoover, M., Miller T.J., and Tjalkens, R., in Optical Biosensors: Present and Future, F. Ligler and C. Rowe-Tait, Eds., Elsevier (Amsterdam), 2002, 407-536.    [Invited book chapter]
  • “Production, Characteristics and Applications of Fluorescent PEBBLE Nano-Sensors: Potassium, Oxygen, Calcium and pH Imaging Inside Live Cells”, Brasuel, M., Aylott, J.W., Clark, H.A., Xu, H, Kopelman, R., Hoyer, M., Miller, T.J., Tjalkens, R. and Philbert, M., Review, in Sensors and Materials, S. Barker, Ed., (M.Y.U. KK, Tokyo, Japan), 2002.  [Invited Review]
  • “Optochemical Nanosensors for Noninvasive Cellular Analysis”, Barker, S.L.R., Clark, H.A. and Kopelman, R. in Biomedical Diagnostic Science and Technology, Law, Akmall and Usmani, Eds., Chapter 7, 139-164, Marcel Dekker, Inc. (New York), 2002.  [Invited Book Chapter]

Review Article

  • “Nanosensors for Diabetic Care”, Cash, K. and Clark, H.A., Trends in Molecular Medicine, 2010, in press.

Patents

  • “Fluorescent Redox Sensor for Cellular Analysis”, Clark, H.A., provisional filed 2008.
  • “iCVD Coatings for Increasing Biocompatibility and Robustness of Optode Sensors”, Gleason, K.K., Baxamusa, S.H., Clark, H.A., Dubach, J.M., provisional filed 2008.
  • “Endosomal escape”, Clark, H.A., provisional filed 2007.
  • “Ion-selective sensors”, Clark, Heather A.; Harjes, Daniel I.; Dubach, John M., PCT Int. Appl.  (2009), 81pp.
  • “Ion-selective quantum dots”, Clark, Heather A.; Harjes, Daniel I.; Dubach, John M.  (USA).    U.S. Pat. Appl. Publ.  (2008), 34pp.
  • “Optode, apparatus, and method for reaction sensing in living cells”, Clark, Heather, PCT Int. Appl.  (2008), 42pp.
  • “Systems and methods of voltage-gated ion channel assays”, Harjes, Daniel I.; Clark, Heather A., U.S. Pat. Appl. Publ.  (2008), 28pp.
  • “Sensor particles for the detection of diols and carbohydrates using boronic acid chelators for glucose”, Clark, Heather A., PCT Int. Appl.  (2008), 44pp.
  • “Optical Sensors for the Detection of Nitric Oxide”, Kopelman, R., Barker, S.L.R., Clark, H.A., US Patent #6,636,652, 2003.
  • “Optical Fiberless Sensors”, Kopelman, R., Clark, H.A., and Philbert, M., US Patent #6,379,955, 2002.
  • “Optical Sensors for the Detection of Nitric Oxide”, Kopelman, R., Barker, S.L.R., Clark, H.A., US Patent #6,272,262, 2001.
  • “Optical fiberless sensors for analyzing cellular analytes”, Clark, H.A., Kopelman, R., et.al. US Patent #6,143,558, 2000.
  • “Optical sensors for the detection of nitric oxide”, Kopelman, R., Barker, S.L.R., Clark, H.A., US Patent #6,002,817, 1999.
  • “Targeted Fiberless Photonic Effectors”, Kopelman, R., Aylott, J., Clark, H.A., Monson, E. and Philbert, M., U.S. Patent (resubmitted November 2001), Serial No.: 09/336,314.